The Effect of Kawa Daun Gambir (Uncaria gambir Roxb.) on the Malondialdehyde (MDA) Level of Heart Alloxan Induced Hyperglycemia Mice

Kadri, Husnil and A’raaf, Muhammad and Julizar, Julizar (2019) The Effect of Kawa Daun Gambir (Uncaria gambir Roxb.) on the Malondialdehyde (MDA) Level of Heart Alloxan Induced Hyperglycemia Mice. In: CONFERENCE PROCEEDING 3rd INTERNATIONAL CONFERENCE ON SECURITY IN FOOD, RENEWABLE RESOURCES, AND NATURAL MEDICINES 2019 (SFRN 2019). pusat penelitian dan pengabdian pada masyarakat Politeknik Pertanian Negeri Kupang. ISBN 9786025126284

Text The Effect of Kawa Daun Gambir (Uncaria gambir Roxb.) on the Malondialdehyde (MDA) Level of Heart Alloxan Induced Hyperglycemia Mice.pdf Download (429kB)

Abstract

Kawa Daun Gambir is steeping gambir leaves containing catechins, antioxidant compounds that can reduce free radical activity and reduce the progressivity of complications caused by oxidative stress. The objective of this study was to determine the effect of Kawa Daun Gambir on levels of malondialdehyde (MDA) in the heart of hyperglycemic mice induced by alloxan. This research was experimental laboratory research with a post-test only control group design. The study was conducted on 30 mice divided into five groups. The first group was considered as a negative control group. The third, fourth and fifth groups were considered as the treated groups 1, 2 and which were induced by alloxan and given Kawa Daun Gambir with different doses for 14 days. The heart malondialdehyde (MDA) levels were examined by using a spectrophotometer. Data analysis was performed using by One Way Anova and Least Significant Differences (LSD). The results of the study showed that there were differences between heart malondialdehyde levels, the positive control group, and the treatment group. There were differences in the mean levels of malondialdehyde (MDA) between groups (p<0,05). Mice heart malondialdehyde levels in the treatment group (mean±SD) were 7.29±0.91 nmol/ml, 6.75±0.96 nmol/ml, and 7.06±0.15 nmol/ml lower than positive control group (K+) 8.51±0.63 nmol/ml. The study concludes that Kawa Daun Gambir can reduce the levels of malondialdehyde (MDA) in the heart of hyperglycemic mice induced by alloxan.

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