AKTIFITAS SITOTOKSIK EKSTRAK DAN SENYAWA HASIL ISOLASI DARI KULIT BATANG MATOA (POMETIA PINNATA FORST & FORST)

Trimedona, Neni and Nurdin, E and Darwis, Djaswir and Efdi, Mai (2017) AKTIFITAS SITOTOKSIK EKSTRAK DAN SENYAWA HASIL ISOLASI DARI KULIT BATANG MATOA (POMETIA PINNATA FORST & FORST). In: PROSIDING SEMIRATA 2017 BIDANG MIPA BKS-PTN WILAYAH BARAT. Fakultas Keguruan dan Ilmu Pendidikan (FKIP) bekerjasama dengan Fakultas Sains dan Teknologi (FST) Universitas Jambi, Jambi. ISBN 978-602-50593-0-8

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Abstract

The aim of this study to measure the toxicity level of matoa (Pometia pinnata Forst & Forst) extracts using brine shrimp lethality test (BSLT) and evaluated of cytotoxicity the isolated compound from nhexane extract against murine leukemia (P388) cell line using a tetrazolium-based colorimetric celluler assay. The isolated compound were identified as taraxerone based on spectroscopic data and compared with literature. The toxicity test of extracts showed that the n-hexane extract have the highest activity with LC50 of 33,10 µg/mL. Although the taraxerone showed the high activity against Artemia salina with LC50 20,10 µg/mL, but this compound did not exhibited toxicity against murine leukemia (P388) with IC50 121,83 µg/mL. Keywords: Matoa, Artemia salina, P388, cytotoxic, IC50

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